{"id":34,"date":"2026-10-13T01:53:23","date_gmt":"2026-10-13T01:53:23","guid":{"rendered":"https:\/\/fgvhp.com\/vhp-glossary\/"},"modified":"2026-10-13T01:53:23","modified_gmt":"2026-10-13T01:53:23","slug":"vhp-glossary","status":"publish","type":"page","link":"https:\/\/fgvhp.com\/ru\/vhp-glossary\/","title":{"rendered":"\u0413\u043b\u043e\u0441\u0441\u0430\u0440\u0438\u0439 VHP"},"content":{"rendered":"\n
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Home<\/a> \/ VHP Knowledge<\/a> \/ Glossary<\/span><\/div>\n Reference \u00b7 English\u2013Chinese<\/span>\n

VHP bio-decontamination glossary<\/h1>\n

66 terms used in VHP cycle design, equipment and validation, each with a short definition and the Chinese term used by Fenggu engineers \u2014 useful when specifications, drawings and validation documents move between English and Chinese.<\/p>\n<\/div><\/section>\n

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Core concepts<\/a>Cycle phases<\/a>Systems and components<\/a>Efficacy and microbiology<\/a>GMP and validation<\/a>Applications<\/a><\/p>\n

Core concepts \u6838\u5fc3\u6982\u5ff5<\/span><\/h2>
Biodecontamination \/ Bio-decontamination<\/b>\u751f\u7269\u9664\u6c61\u67d3<\/span><\/dt>
Reducing viable microorganisms on the exposed surfaces of a room, enclosure or piece of equipment to a defined level \u2014 for VHP usually demonstrated as a 6-log reduction of bacterial spores on biological indicators. It treats surfaces, not the inside of products.<\/dd><\/div>
Decontamination<\/b>\u51c0\u5316 \/ \u53bb\u6c61<\/span><\/dt>
Removing or inactivating contaminants \u2014 microbial, chemical or particulate \u2014 so an item or area is safe for its next use. A broader term than biodecontamination.<\/dd><\/div>
Vaporized Hydrogen Peroxide (VHP)<\/b>\u6c7d\u5316\u8fc7\u6c27\u5316\u6c22\uff08VHP\uff09<\/span><\/dt>
Hydrogen peroxide solution, typically 30\u201335% w\/w, flash-vaporized and delivered into a sealed space as a low-temperature, sporicidal vapour. What VHP decontamination is \u2192<\/a><\/dd><\/div>
Hydrogen peroxide vapour<\/b>\u8fc7\u6c27\u5316\u6c22\u84b8\u6c7d<\/span><\/dt>
The gaseous hydrogen peroxide, together with water vapour, that a VHP generator produces. It is the active agent in contact with surfaces during the cycle.<\/dd><\/div>
Cold sterilization<\/b>\u4f4e\u6e29\u706d\u83cc<\/span><\/dt>
Sterilization or decontamination at or near room temperature, without the heat of steam or dry-heat processes. Suitable for heat-sensitive materials, plastics and electronics.<\/dd><\/div>
Sterilant<\/b>\u706d\u83cc\u5242<\/span><\/dt>
An agent able to kill all forms of microbial life, including bacterial spores. In a VHP process the sterilant is the hydrogen peroxide solution.<\/dd><\/div>
Antimicrobial (broad-spectrum)<\/b>\uff08\u5e7f\u8c31\uff09\u6297\u83cc\u5242<\/span><\/dt>
Effective against a wide range of organisms \u2014 bacteria, fungi, viruses and bacterial spores \u2014 rather than a single group.<\/dd><\/div>
Sporicidal<\/b>\u6740\u82bd\u5b62\u7684<\/span><\/dt>
Able to kill bacterial spores, the most resistant form of microbial life. EU GMP Annex 1 expects a sporicidal agent in the cleanroom disinfection programme.<\/dd><\/div>
Residue-free<\/b>\u65e0\u6b8b\u7559<\/span><\/dt>
Hydrogen peroxide breaks down into water and oxygen, so surfaces do not need to be wiped down after the cycle \u2014 a key advantage over formaldehyde.<\/dd><\/div>
Saturation \/ dew point<\/b>\u9971\u548c \/ \u9732\u70b9<\/span><\/dt>
The point at which air cannot hold more vapour; beyond it, vapour condenses on surfaces. Cycle design controls humidity and concentration relative to this point. VHP concentration, humidity and condensation \u2192<\/a><\/dd><\/div>
Enclosure \/ Chamber<\/b>\u5bc6\u95ed\u7a7a\u95f4 \/ \u8154\u4f53<\/span><\/dt>
The sealed volume being treated \u2014 a room, isolator, pass box, filter housing or the chamber of a piece of equipment.<\/dd><\/div><\/dl>

Cycle phases \u5faa\u73af\u9636\u6bb5<\/span><\/h2>
Dehumidification<\/b>\u9664\u6e7f<\/span><\/dt>
Phase 1. The relative humidity in the enclosure is lowered so that more hydrogen peroxide can be held as vapour without condensing.<\/dd><\/div>
Conditioning<\/b>\u8c03\u8282<\/span><\/dt>
Phase 2. Vapour is injected at a high rate to bring the concentration up to the target quickly and evenly.<\/dd><\/div>
Decontamination \/ Sterilization (phase)<\/b>\u706d\u83cc<\/span><\/dt>
Phase 3. The concentration is held for the validated dwell time, during which microorganisms on exposed surfaces are inactivated.<\/dd><\/div>
Aeration<\/b>\u901a\u6c14<\/span><\/dt>
Phase 4. The vapour is removed \u2014 catalytically, by exhaust, or both \u2014 until the concentration is below the release limit, often 1 ppm. VHP aeration time calculator \u2192<\/a><\/dd><\/div><\/dl>

Systems and components \u7cfb\u7edf\u4e0e\u90e8\u4ef6<\/span><\/h2>
Closed-loop \/ open-loop<\/b>\u5c01\u95ed\u73af\u8def \/ \u5f00\u653e\u5f0f\u73af\u8def<\/span><\/dt>
In a closed loop, air from the enclosure passes through the generator and returns to it. In an open loop, fresh air is drawn in and the treated air is exhausted.<\/dd><\/div>
Recirculating system<\/b>\u518d\u5faa\u73af\u7cfb\u7edf<\/span><\/dt>
A generator that forms a closed loop with an enclosure or piece of equipment through supply and return connections.<\/dd><\/div>
Catalytic converter<\/b>\u50ac\u5316\u8f6c\u5316\u5668<\/span><\/dt>
An element that breaks hydrogen peroxide down into water and oxygen, used to shorten aeration and to make exhaust air safe.<\/dd><\/div>
Flash vaporization<\/b>\u95ea\u84b8<\/span><\/dt>
Injecting the liquid onto a hot surface so it vaporizes instantly and completely, keeping the peroxide-to-water ratio of the solution in the vapour. How a VHP generator works \u2192<\/a><\/dd><\/div>
VHP generator<\/b>VHP \u53d1\u751f\u5668<\/span><\/dt>
The equipment that dehumidifies, vaporizes and injects hydrogen peroxide, monitors concentration, humidity and temperature, and controls the cycle.<\/dd><\/div>
Skid<\/b>\u64ac\u5757 \/ \u6a21\u5757<\/span><\/dt>
Equipment pre-assembled on a frame and delivered as a single module, ready to connect to site utilities.<\/dd><\/div>
Manifold<\/b>\u5206\u914d\u7ba1\u6c47 \/ \u591a\u652f\u7ba1<\/span><\/dt>
Distribution piping that splits the vapour flow between several outlets or rooms.<\/dd><\/div>
Balancing damper<\/b>\u5e73\u8861\u98ce\u9600<\/span><\/dt>
A damper set to balance airflow between branches of a duct system, so each room receives its share of vapour.<\/dd><\/div>
Ductwork<\/b>\u7ba1\u9053 \/ \u98ce\u7ba1\u7cfb\u7edf<\/span><\/dt>
The air distribution ducts. In HVAC-integrated VHP the ducts carry the vapour, so their materials and leak-tightness matter.<\/dd><\/div>
HEPA filter \/ pre-filter<\/b>\u9ad8\u6548\u8fc7\u6ee4\u5668\uff08HEPA\uff09\/ \u9884\u8fc7\u6ee4\u5668<\/span><\/dt>
High-efficiency particulate air filter (for example H13 or H14 under EN 1822); the pre-filter upstream protects it from coarse dust.<\/dd><\/div>
AHU (Air Handling Unit)<\/b>\u7a7a\u6c14\u5904\u7406\u673a\u7ec4\uff08AHU\uff09<\/span><\/dt>
The unit that conditions, filters and moves air for a cleanroom suite. An HVAC-integrated VHP system distributes vapour through it.<\/dd><\/div>
HVAC<\/b>\u6696\u901a\u7a7a\u8c03\uff08HVAC\uff09<\/span><\/dt>
Heating, ventilation and air conditioning \u2014 the building systems that control temperature, humidity, pressure and air changes.<\/dd><\/div>
Desiccant dehumidifier<\/b>\u8f6c\u8f6e\u9664\u6e7f\u673a<\/span><\/dt>
A dehumidifier using a rotating desiccant wheel to remove moisture, able to reach low humidity faster than cooling alone.<\/dd><\/div>
Air exchange<\/b>\u6362\u6c14\u6b21\u6570<\/span><\/dt>
How many times the air volume of a space is replaced per hour. It governs how fast vapour is diluted during aeration.<\/dd><\/div>
Injection rate<\/b>\u6ce8\u5165\u901f\u7387<\/span><\/dt>
The mass of hydrogen peroxide solution vaporized per minute, usually in g\/min.<\/dd><\/div>
Operator interface \/ touch panel<\/b>\u64cd\u4f5c\u754c\u9762 \/ \u89e6\u6478\u5c4f<\/span><\/dt>
The screen used to start cycles, select recipes, view live values and review records.<\/dd><\/div>
Interlocked doors<\/b>\u4e92\u9501\u95e8<\/span><\/dt>
Doors that cannot be opened at the same time, so air and contamination cannot pass straight through. Cleanroom airlock types \u2192<\/a><\/dd><\/div>
Double gasket door<\/b>\u53cc\u5bc6\u5c01\u95e8<\/span><\/dt>
A door sealed by two gaskets for better leak-tightness, used where vapour or containment must not escape.<\/dd><\/div>
Pass-through hatch \/ pass box<\/b>\u4f20\u9012\u7a97 \/ \u4f20\u9012\u8231<\/span><\/dt>
A small chamber with interlocked doors in a cleanroom wall for transferring materials; a VHP pass box also decontaminates their outer surfaces. VHP pass box guide \u2192<\/a><\/dd><\/div>
Diffuser \/ nozzle<\/b>\u6269\u6563\u5668 \/ \u55b7\u5634<\/span><\/dt>
The outlet that releases vapour into the space and helps distribute it.<\/dd><\/div>
PLC \/ SCADA<\/b>PLC \/ SCADA<\/span><\/dt>
Programmable logic controller and supervisory control and data acquisition \u2014 the control and data systems of the equipment and plant.<\/dd><\/div><\/dl>

Efficacy and microbiology \u706d\u83cc\u6548\u529b\u4e0e\u5fae\u751f\u7269<\/span><\/h2>
6-log reduction<\/b>\u964d\u4f4e 6 \u4e2a\u5bf9\u6570\u7ea7\uff0899.9999%\uff09<\/span><\/dt>
A reduction of the viable count by a factor of one million, usually shown on biological indicators carrying at least 10\u2076 spores. Biological indicators and the 6-log reduction \u2192<\/a><\/dd><\/div>
SAL 10\u207b\u2076 (Sterility Assurance Level)<\/b>\u65e0\u83cc\u4fdd\u8bc1\u6c34\u5e73 SAL 10\u207b\u2076<\/span><\/dt>
A probability of no more than one non-sterile item in a million after sterilization. It applies to terminally sterilized products; surface biodecontamination is normally specified as a log reduction.<\/dd><\/div>
Log reduction<\/b>\u5bf9\u6570\u7ea7\u4e0b\u964d<\/span><\/dt>
The reduction in viable microorganisms expressed in powers of ten: 1-log is 90%, 3-log is 99.9%, 6-log is 99.9999%.<\/dd><\/div>
Biological Indicator (BI)<\/b>\u751f\u7269\u6307\u793a\u5242<\/span><\/dt>
A carrier inoculated with a known population of resistant spores. Growth or no growth after incubation shows whether the cycle reached that location.<\/dd><\/div>
Chemical Indicator (CI)<\/b>\u5316\u5b66\u6307\u793a\u5242<\/span><\/dt>
An indicator that changes colour on exposure to hydrogen peroxide. It shows that vapour reached a location, not that microorganisms were killed.<\/dd><\/div>
Geobacillus stearothermophilus<\/b>\u55dc\u70ed\u8102\u80aa\u5730\u82bd\u5b62\u6746\u83cc<\/span><\/dt>
A spore-forming bacterium highly resistant to hydrogen peroxide, used as the standard test organism in VHP biological indicators.<\/dd><\/div>
Bacterial spores<\/b>\u7ec6\u83cc\u82bd\u5b62<\/span><\/dt>
The dormant, highly resistant form of some bacteria. Killing spores is the benchmark for a sporicidal process.<\/dd><\/div>
Settle plate<\/b>\u6c89\u964d\u83cc\u5e73\u76bf<\/span><\/dt>
An open agar plate exposed for a set time to collect microorganisms settling from the air.<\/dd><\/div>
Contact plate<\/b>\u63a5\u89e6\u789f<\/span><\/dt>
An agar plate pressed onto a flat surface to sample the microorganisms on it.<\/dd><\/div>
Glove print<\/b>\u624b\u5957\u5370<\/span><\/dt>
Fingertips of a glove pressed onto agar to monitor glove contamination after aseptic operations. Isolator glove integrity testing \u2192<\/a><\/dd><\/div>
cfu (colony-forming unit)<\/b>\u83cc\u843d\u5f62\u6210\u5355\u4f4d\uff08CFU\uff09<\/span><\/dt>
A unit for counting viable microorganisms: each colony on an agar plate is assumed to come from one viable unit.<\/dd><\/div><\/dl>

GMP and validation GMP\u4e0e\u9a8c\u8bc1<\/span><\/h2>
EU GMP Annex 1<\/b>\u6b27\u76df GMP \u9644\u5f551<\/span><\/dt>
The EU guideline for the manufacture of sterile medicinal products, revised in 2022, which sets expectations for contamination control, cleanrooms and barrier systems. EU GMP Annex 1 overview \u2192<\/a><\/dd><\/div>
Grade A \/ B \/ C \/ D<\/b>A \/ B \/ C \/ D \u7ea7<\/span><\/dt>
EU GMP cleanroom grades. Grade A is the critical zone for aseptic operations; B is its background for open processing; C and D are for less critical stages.<\/dd><\/div>
Validation \/ validatable<\/b>\u9a8c\u8bc1 \/ \u53ef\u9a8c\u8bc1<\/span><\/dt>
Documented evidence that a process consistently produces the intended result. A validatable cycle is reproducible and measurable enough to be proven.<\/dd><\/div>
IQ \/ OQ \/ PQ<\/b>\u5b89\u88c5\u786e\u8ba4 \/ \u8fd0\u884c\u786e\u8ba4 \/ \u6027\u80fd\u786e\u8ba4<\/span><\/dt>
Installation, operational and performance qualification: confirming the equipment is installed correctly, operates as specified, and performs reliably in real use. VHP cycle development and IQ\/OQ\/PQ \u2192<\/a><\/dd><\/div>
FAT \/ SAT<\/b>\u5de5\u5382\u9a8c\u6536\u6d4b\u8bd5 \/ \u73b0\u573a\u9a8c\u6536\u6d4b\u8bd5<\/span><\/dt>
Factory and site acceptance tests: checking the equipment against the specification before shipment and again after installation. Isolator FAT and SAT checklist \u2192<\/a><\/dd><\/div>
P&ID<\/b>\u7ba1\u9053\u53ca\u4eea\u8868\u56fe\uff08P&ID\uff09<\/span><\/dt>
Piping and instrumentation diagram: the drawing of process lines, valves, instruments and control connections.<\/dd><\/div>
Thermocouple probe<\/b>\u70ed\u7535\u5076\u63a2\u5934<\/span><\/dt>
A temperature sensor used to map temperature in the enclosure during cycle development and qualification.<\/dd><\/div>
Cycle development<\/b>\u5faa\u73af\u5f00\u53d1<\/span><\/dt>
The work of setting cycle parameters for a specific enclosure and load, and confirming them with indicators, before qualification.<\/dd><\/div>
Load \/ load configuration<\/b>\u8d1f\u8f7d \/ \u88c5\u8f7d\u65b9\u5f0f<\/span><\/dt>
What is inside the enclosure during the cycle, and how it is arranged. A change in load can change the cycle result.<\/dd><\/div>
URS \/ FS \/ DQ<\/b>\u7528\u6237\u9700\u6c42\u8bf4\u660e \/ \u529f\u80fd\u8bf4\u660e \/ \u8bbe\u8ba1\u786e\u8ba4<\/span><\/dt>
User requirement specification, functional specification and design qualification \u2014 the documents that define what is needed and confirm the design meets it.<\/dd><\/div>
Utility requirements<\/b>\u516c\u7528\u5de5\u7a0b\u8981\u6c42<\/span><\/dt>
The services the equipment needs on site, such as power, compressed air, exhaust and network connections.<\/dd><\/div>
Scope of supply \/ work<\/b>\u4f9b\u8d27\u8303\u56f4 \/ \u5de5\u4f5c\u8303\u56f4<\/span><\/dt>
What the supplier delivers and what work it performs, as distinct from what the customer provides.<\/dd><\/div>
Relative humidity (RH)<\/b>\u76f8\u5bf9\u6e7f\u5ea6<\/span><\/dt>
The water vapour in air as a percentage of the maximum it could hold at that temperature. It limits how much peroxide vapour the air can carry.<\/dd><\/div>
Material compatibility<\/b>\u6750\u6599\u517c\u5bb9\u6027<\/span><\/dt>
Whether materials tolerate repeated exposure to hydrogen peroxide, and whether they absorb it and slow aeration. VHP material compatibility \u2192<\/a><\/dd><\/div><\/dl>

Applications \u5e94\u7528\u573a\u666f<\/span><\/h2>
Aseptic filling<\/b>\u65e0\u83cc\u704c\u88c5<\/span><\/dt>
Filling sterile product into sterile containers in a Grade A environment, often inside an isolator. Hydrogen peroxide uptake in isolator filling \u2192<\/a><\/dd><\/div>
Sterility testing<\/b>\u65e0\u83cc\u68c0\u67e5<\/span><\/dt>
The pharmacopoeial test for sterility of finished product, usually performed in an isolator to avoid false positives.<\/dd><\/div>
Biological Safety Cabinet (BSC)<\/b>\u751f\u7269\u5b89\u5168\u67dc<\/span><\/dt>
A ventilated cabinet that protects the operator, the product and the environment when handling biological agents.<\/dd><\/div>
BSL-3 \/ BSL-4<\/b>\u751f\u7269\u5b89\u5168 3 \u7ea7 \/ 4 \u7ea7<\/span><\/dt>
Biosafety levels for laboratories handling serious or life-threatening agents, with sealed rooms that are decontaminated as a whole.<\/dd><\/div>
Material transfer<\/b>\u7269\u6599\u4f20\u9012<\/span><\/dt>
Moving materials into or out of a controlled area without bringing contamination with them \u2014 by pass box, airlock or transfer port. VHP equipment selector \u2192<\/a><\/dd><\/div><\/dl><\/div>\n