{"id":12,"date":"2026-10-12T06:37:34","date_gmt":"2026-10-12T06:37:34","guid":{"rendered":"https:\/\/fgvhp.com\/applications\/isolator-rabs-decontamination\/"},"modified":"2026-10-12T06:37:34","modified_gmt":"2026-10-12T06:37:34","slug":"isolator-rabs-decontamination","status":"publish","type":"page","link":"https:\/\/fgvhp.com\/ru\/applications\/isolator-rabs-decontamination\/","title":{"rendered":"\u0411\u0438\u043e\u0434\u0435\u043a\u043e\u043d\u0442\u0430\u043c\u0438\u043d\u0430\u0446\u0438\u044f VHP \u0434\u043b\u044f \u0438\u0437\u043e\u043b\u044f\u0442\u043e\u0440\u043e\u0432 \u0438 RABS"},"content":{"rendered":"\n\n
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Home<\/a> \/ Applications<\/a> \/ Isolators & RABS<\/span><\/div>\n Application \u00b7 Isolators & RABS<\/span>\n

VHP Bio-decontamination for Isolators and RABS<\/h1>\n

An isolator is only as good as the decontamination step that starts each campaign. Integrated or connected VHP brings the closed chamber, gloves and exposed surfaces to a validated state before product is exposed.<\/p>\n

Request a Free Application Review<\/a><\/div>\n <\/div>\n
\"Fenggu<\/div>\n<\/div><\/section>\n\n
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The challenge<\/span>

Why this needs a VHP step<\/h2><\/div>\n

Because the isolator is a sealed, small volume, it can be decontaminated reproducibly \u2014 far more reliably than a room. That reproducibility is what lets isolators sit in a lower-grade background while protecting a Grade A interior.<\/p>

The difficulties are the details: glove fingers, mated surfaces, transfer ports and materials inside the chamber, and getting residual peroxide down to a level that will not affect the product.<\/p><\/div>\n<\/div><\/section>\n\n

\n Typical configuration<\/span>

Equipment options<\/h2>\n
FG-ISO-AF<\/span>

Aseptic filling isolator<\/h3>

Integrated VHP biodecontaminates exposed interior surfaces before every campaign; unidirectional airflow, H14 HEPA, pressure and particle monitoring.<\/p>View specifications \u2192<\/span><\/a>FG-ISO-ST<\/span>

Sterility test isolator<\/h3>

Reserved VHP generator port to decontaminate the chamber and exposed surfaces before testing, reducing false positives.<\/p>View specifications \u2192<\/span><\/a>FG-ISO-CC<\/span>

Cell processing isolator<\/h3>

Dry VHP decontamination between processes, with temperature control during the cycle to protect cell viability.<\/p>View specifications \u2192<\/span><\/a><\/div>\n \n<\/div><\/section>\n\n

\n Engineering & validation<\/span>

What to plan for<\/h2>\n
01<\/span>

Integrated or connected?<\/h3>

Integrated generators give the shortest, most repeatable cycles and fixed piping. A port for an external generator costs less and suits sterility-test or low-frequency use. Decide based on how often you decontaminate.<\/p><\/div>

02<\/span>

Gloves and ports are the worst cases<\/h3>

Glove fingers, folds, door gaskets and transfer-port seals are where VHP contact is weakest. Stretch gloves during the cycle and put biological indicators there during qualification.<\/p><\/div>

03<\/span>

Load inside the chamber<\/h3>

Anything left inside \u2014 tools, consumables, components \u2014 becomes part of the validated load. Absorbent plastics and filters take up peroxide and lengthen aeration.<\/p><\/div>

04<\/span>

Residuals and the product<\/h3>

Some products, especially biologics and cell cultures, are sensitive to low levels of residual H\u2082O\u2082. Set the aeration end-point from product risk, not just operator safety.<\/p><\/div>

05<\/span>

Leak test before gassing<\/h3>

A pressure-decay leak test before each cycle confirms the chamber is tight, both for decontamination performance and for operator protection.<\/p><\/div><\/div>\n<\/div><\/section>\n\n

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Before you ask for a quote<\/span>

Information an engineer will need<\/h2>

Having these ready makes the first recommendation specific instead of generic.<\/p><\/div>\n

  • Isolator type and process (filling, sterility test, cell processing)<\/li>
  • Chamber volume and number of glove ports<\/li>
  • Positive or negative pressure<\/li>
  • Decontamination frequency<\/li>
  • Product sensitivity to residual peroxide<\/li>
  • Transfer devices (RTP, pass box) connected<\/li><\/ul>\n<\/div><\/section>\n\n\n
    \n FAQ<\/span>

    Common questions<\/h2>\n
    Can a RABS be decontaminated with VHP?<\/summary>

    A closed RABS can be gassed with doors shut; an open RABS (oRABS) is normally decontaminated together with the surrounding room, for example with a mobile generator or an HVAC-integrated system.<\/p><\/details>

    How long does an isolator VHP cycle take?<\/summary>

    It depends on volume, load, materials and the residual end-point. Aeration usually dominates. The cycle time is fixed during cycle development for the specific isolator and load.<\/p><\/details>

    Is VHP decontamination the same as sterilisation?<\/summary>

    VHP in an isolator is a surface bio-decontamination step, qualified as a \u2265 6-log sporicidal reduction. Product-contact items are normally sterilised separately and brought in through validated transfers.<\/p><\/details><\/div>\n<\/div><\/section>\n